Villena is a provincial town and has no airport. That is why to get to Istanbul, you need to reach a larger city close to Villena first, from there you'll be able to fly.
It is impossible to buy direct flights Villena — Istanbul, because the former does not have an airport. However, pretty close the following airports are to be found:
Find the best accommodation in Istanbul on hotels.anywayanyday.com: search for hotels by price, popularity, trip ranking, accommodation type and rendered services.
